Ten former University of Pittsburgh (Pitt) players have been elected to the Pro Football Hall of Fame, including:
- Darrelle Revis: Cornerback who played for the Panthers from 2004–2006 and was elected in 2023
- Jimbo Covert: Offensive tackle who played for the Panthers from 1978–1982 and was elected in 2020
- Mike Ditka: Tight end who was elected in 1988
- Chris Doleman: Defensive end/linebacker who was elected in 2012
- Tony Dorsett: Running back who was elected in 1994
- Russ Grimm: Offensive lineman who was elected in 2010
- Rickey Jackson: Linebacker who was elected in 2010
- Dan Marino: Quarterback who was elected in 2005
- Curtis Martin: Running back who was elected in 2012
- Joe Schmidt: Linebacker who was elected in 1973