Look at the last 3 weeks. We played USF in 100 degree heat, they run the fastest tempo in football, and we were their Super Bowl. We won the game convincingly because we're the better team, but we had players dropping like flies with cramps and overheating and exhaustion. But we win.
Then we play Virginia Tech on six days of rest on the following Friday. That's a rivalry game, we are their Super Bowl. We still win.
Then we fly 3000 miles to play Cal. The game doesn't end until 2:30 AM. Cal has a BYE the week before, it's their first ever College Gameday, and so we're their Super Bowl. We come out flat but we still win.
Nobody is talking about it, but WE WERE JUST TIRED. That was a brutal stretch.
A lot of the defensive issues - missed assignments, missed tackles - those things will be corrected with nothing more than just getting proper rest.
I think we come out and blow Louisville out. We're a much better team than they are, and we'll be healthy and rested. This will look a lot more like the first couple weeks than the last couple IMO.