To get the plus one advantage and have the running back be the ball carrier against a 6 man box, the offense must leave a defender unblocked and keep the seventh defender from entering. With the RPO, any run can be used. Some like zone, some like gap based power runs. In this example, the run will be the common inside zone run, and the pass will be a hitch and fade on the front and the backside route will be an out and fade.
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The quarterback will take the snap and immediately get his eyes to the conflicted defender. If that defender comes downhill to fill the B gap, the quarterback will pull and throw to the slot receiver who is going to make sure to body up and block out any safety who may be coming down to rob. By leaving the linebacker unblocked, the offense gains a plus one in the run game. By separating the field and sending routes deep, it forces safeties to remain out of the run game, ie to keep the seventh defender out. Because the backside is running a speed out, the defender over him will be unable to come into the run box. As defenses adjust to what is happening the offense must continue understand what gaps or passing zones are being left open, or being defended by dual defenders. As long as the offense knows the answer to that question, there is an RPO to attack with. Ultimately, the final chalk lies with a cover zero. At that point, it is my man against your man. Play ball.