The best to ever do it is Jared Lorenzen also known as Hefty Lefty, aka Pillsbury throw Boy.. J/K but RIP to the big man!
On a serious note Vince Young, Reggie Bush, Andrew Luck took games over all by themselves but I'm a defensive guy so for overall stout career I'm going with:
Luke Kuechly at BC he was (what the youngin's say now days HIM!) a pesky nose for the ball menace that was all over the field, took over for starting OLB Mark Herzlich in 2009 who had bone cancer, he led the ACC and ranked second nationally in tackles in his
true freshman season with 158, including 87 solo tackles.
2010 Sophomore season he moved to middle linebacker and led the country in tackles with 163 including 97 solo tackles.
2011 Junior season, he won the Butkus Trophy, Nagurski Trophy, Lombardi Award, and Jack Lambert Trophy tallying 191 tackles including 102 solo tackles. 2011 ACC Defensive Player of the Year and a three-time First Team All-ACC selection.
Finished his college career from 2009-2011 with 532 tackles, which is
THIRD in NCAA history and the two players above him played 2019-2024 with 555 tackles and 2018-2022 with 577 tackles.. DO THE MATH
While Boston College at the time wasn't playing anyone elite his numbers were mind boggling and was a pleasure to watch except for the 45 yard pick six thrown by Jacory for his 4th pick of the game giving BC a ten point lead and the game-clinching score. Pshhh
My boy KONG SUH from Nebraska (unfortunately I'm a closet Husker) with gaudy video game like numbers is runner up.