I doubt it. The rules today favor a wide open offense. Not so much back then. The game was played different and rougher than it is today. Going against stacked lines, with 7/8 in the box, was the norm. It was the era of the middle LB (Butkis, Huff, Nietske, Nobis, Bednarick, George, Schmidt, Lucci, etc.). It was a time when you stopped the RB, you won the game. There weren't many teams that could expose DBs like today. Most team didn't employ zone coverages, there was no need. Also, it was before the league was watered down with expansion.
This has been debated here before, I know what you're going to say, today they're bigger and faster. But if you take a Jim Brown and submit him to the nutritional and training regimens of today, they would also be bigger and faster. The truly great ones would be great in any era.