As usual, what was in Madden last year, is on here this year. So the physics engine changes the feel drastically from last year. To me anyway.
Running the ball is amazing to me. The ability to combo jukes is downright sick. The passing seems revamped as well. Your input will certainly mean more in the passing game. Beau Sandland was a monster for me. Being able to put the pass in tighter spots makes for a more engaging passing experience.
Defensively, the offense will adjust to you more, in a realistic manner. I play a lot of man. Driskel started lighting me up on quick slants, and scrambles. I had to change what I was doing, whereas last year I could get away with it for the whole game.
The changes are somewhat subtle, but the impact isn't so much. Starting Dynasty tonight, I'll try to add more. Hopefully it helps. I've only played two games since I've got it.