Yessir. BBQ, the meat, the cooking, the sauces...everything is driven by the region.
Christopher Columbus brought over pigs on his ships. Until recently, there was still a legacy herd of wild pigs running around on one of the Georga/SC barrier islands that were descended from the Columbus pigs. Pork is the prevalent BBQ ingredient in VA and the Carolinas. The East Carolina sauce uses more vinegar, West Carolina is more tomato based, and South Carolina is mustard based (don't ask me how Alabama got into mayonnaise for its "Alabama white sauce").
Texas obviously has more cattle, and more BBQ beef and brisket and sausage. Texas doesn't use much sauce for cooking, but tends to go more towards spicy.
Memphis was an early trading spot, where goods from all over came together for commerce. The use of molasses was what led to the "sweet" variety of BBQ sauce.
And then KC became a massive trading spot for US commerce, particularly cattle and sheep, the larger herd animals. KC tended to use a mixture of sweet and spicy sauces.
Someone please tell "NC Cane" that the barbecue that started in the Caribbean INVOLVED DEER AND ALLIGATOR. And was first imported to Mississippi, before it made its way to the Carolinas.
You can't just steal something, change the name, and then define it in a way that nobody else can use the same term.