I gave my vote to Hendricks. As one who has seen almost all the greats, going back to Don Bosseler, I think Hendricks was probably the most dominant single player given the quality of the football played during his era. That's not to say he would dominate against 1990s or 2000's competition.
Some of all-time greats who were not on the list include Bosseler, from the mid-50s, and George Mira (the real Matador) from the early '60s.
Otto's achievements were primarily in the pro's.
Hendricks was unreal in how he could dominate one side of a line of scrimmage. He totally screwed up what an offense could do. He had unbelievable range in making tackles just because of his wingspan. An offensive player would block him low, he would lean over and still be able to reach out and grab a ball carrier.
O.J. Simpson, right after he won the Heisman, was on the Tonight Show. He took questions from the audience. One audience member asked who was the hardest hitting player he faced. He said the hardest hitting was Kevin Hardy from Notre Dame. He said the best player he faced was Hendricks, whom he said could not be blocked.