There have been bigger lines than that.
FSU was favored by 70 against Savannah St last year, and I think the '09 Gators were favored by something similar against DeVry or some school like that.
Very true. Memories are apparently conveniently poor. It always has to be the best or the biggest.
I detailed in a post last week that Houston in its run and shoot days was favored by 72.5 to 73.5 points all week while hosting SMU in 1989. I was working as sportsbook supervisor at the time so I remember it very well. There was conversation for months on what the spread would be in that game. My friend sampled every book in town and claimed he briefly saw -74.5 at one joint. That would have been enough for SMU to cover, since they lost 95-21. That number was initially in the 69-70 range, then jumped several points. The standard number all week was -72.5. That's what I was seeing when I got off work and looked at other books. Then at game time it closed all over the place. With lines that high, you'll get one person betting in one direction at one spot, and a move in the opposite direction somewhere else. I heard reports that it closed -69 or -70 at some joints but maintained the -72.5 level at others.
Florida was favored by -63 against Charleston Southern in 2009. That number got some publicity at the time because Danny Sheridan claimed it was -73. That's typical of Sheridan, always trying to get his name out there. He doesn't make lines. He steals them, and not always accurately.
The Houston/SMU game in 1989 was a conference game, although SMU obviously was coming off the death penalty so it was a special situation. The rest of these games with massive spreads are against lower division teams, and always at home. The largest spread I've ever seen on a road game, and it was also a conference game, was Oklahoma at Kansas State in 1987. The Sooners were favored by as much as -60 on the road in that game. The consensus number was -59 all week then it dropped to a mix of -58 and -57 at game time. Oklahoma jumped to a massive lead but leveled out and did not cover, winning 59-10.