OK I see what you were doing. Now that I understand your thought process I can see where you were going with it.
I think that the cool thing about Guidry's defense is that it is so flexible and versatile thus allowing it to transition seamlessly between the packages and even the different fronts you mentioned.
Like you said, we are a base 4-2-5 defense. In the base defense we play with an extra DB which is usually called a Nickel but in Guidry's scheme he calls it the Star position and again like you mentioned, it is in essence a hybrid CB/Safety. Currently, Meesh Powell is the Star. Now for example if we decide to go to a more traditional base 4-3 we will put in the Sam LB and play without the Star. The Sam in Guidry's scheme is a hybrid LB/Safety position. This is what KJ Cloyd played last year and this is the position that Cam Pruitt excelled at during the spring. Remember during spring that Pruitt was being praised for his great instincts, explosion and physicality as well as his ability to cover a WR/RB/TE deep downfield. I expect Pruitt to get a good amount of snaps in this role this year.
As far as the 3-3 looks are concerned, I believe there are a couple of options. Guidry can take his Jack DÈ and stand him up thus creating a 3-3 look or he can pull the Jack and replace him with the Sam LB which gives us a 3-3. Those are just examples I know of however there is a poster named
@WestEndZone had an amazing post and video on this very subject. I highly recommend it as it is very well done.